ea0081ep70 | Adrenal and Cardiovascular Endocrinology | ECE2022
Sharma Vijay
, Coope Helen
, Maskin Kamran
, Parviainen Lotta
, Porter John
, Withe Michael
, Barnes Anne-Marie
Objectives: Congenital adrenal hyperplasia (CAH) is a rare condition caused by enzyme deficiency in cortisol biosynthesis. Patients with CAH require lifelong therapy, with the aim of replacing deficient hormones (cortisol +/− aldosterone) and reducing excess androgen production. Guidelines state that the lowest effective glucocorticoid (GC dose) should be used; however, current GC therapy is suboptimal, and supraphysiological GC doses are used to reduce excess androgens....